In the old town centre of Sangemini, the Hotel Duomo is the perfect holiday destination for anyone wishing to savour the relaxing and charming atmosphere of the Medieval town of San Gemini. The hotel itself is in an 18th century palazzo, formerly the residence of the Princes of Santa Croce, and contains a number of fine architectural details including a richly frescoed room. 

The hotel Duomo offers 32 rooms, of which 4 are suites within the defence towers that look out onto the palazzo's perimeter wall. There are an additional 9 rooms in the palazzo opposite the hotel, which has been recently refurbished. All rooms are equipped with every modern comfort.

The hotel also boasts a conference space able to hold up to 70 people, as well as a restaurant that serves traditional local cuisine from truffles to boletus mushrooms, Umbrian olive oil, asparagus and more delicacies.

Guests of the hotel have use of the facilities at the Il Colle sports centre.